In light of the shortcomings concerning Cross-Border Regional Innovation Systems (CBRIS), this analysis seeks to propose a new Cross-Border Regional Innovation Ecosystem (CBRIE) concept better equipped to address the to address contemporary innovation policy development and practical regional policy challenges on the ground. The existing literature on CBRIS has focused on EU regions and awarded only a marginal role to non-profit organizations (NPO) as potential facilitators of cross-border cooperation (CBC). To address this knowledge gap, the role of NPOs in CBC is analyzed within the bi-national San Diego-Tijuana region at the US-Mexico border. The research follows a mixed approach based on semi-structured interviews and social network analysis in order to: i) gauge how organizations are interrelated and ii) identify the key actors within the CBRIE. The results show that the CBRIE concept serves as an effective tool for identifying the organizations involved in cross-border networks and their roles in CBC at the US-Mexico border. Although the US-Mexico border presents stark differences compared to EU border regions, the CBRIE concept can offer a starting point for analyzing and facilitating CBC in Europe.

During the times of the COVID-19 pandemic, nations have issued unprecedented border closures around the world, yielding abrupt impacts on the movement of goods and people. This has heavily affected the quality of life in border regions, which are often found to be at a disadvantage when compared to other regions in terms of employment, accessibility, social services and economic growth. Based upon developing threads in the literature concerning the untapped potential for development in border regions, we argue that the Mission-Oriented Approach (MOA) can fit well with the ambitious goal to revitalize those territories in the aftermath of the pandemic. Despite the surge of MOA in discourses on innovation policy, we seek to implement it in a regional development perspective, pursuing both economic and social policy objectives. The authors unravel the policy concept of MOA into three main aspects: (I) address a sound societal challenge; (II) Research & Development (R&D) regional agenda embedded in a cross-border regional development vision; (III) mobilizing multiple cross-sectorial projects. Through a desk study analysis, the authors draw insights from selected case studies where these aspects have been implemented to inspire policy intervention in the aftermath of COVID-19. This paper presents the MOA theoretical model, which has potential explanatory power in other cross-border regions.

This paper investigates the main forces driving economic integration in cross-border regions (CBRs). Drawing on the proximity framework, it contends that all four forms of proximity need to be stressed in cross-border regional economic integration discourses. The paper is based on a comparison of two cross-border regional contexts in North America, which have been investigated using a survey and semi-structured interviews. Based upon the data collected, the two case studies shed a light on cognitive proximity as an underestimated driver in CBRs. Moreover, the cross-border regional identity as well as the access to a talented workforce emerge as remarkable assets to leverage through appropriate cross-border regional policies. ARTICLE HISTORY

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