Positron emission tomography/computed tomography (PET/CT) has had a great impact in oncology; in this field, PET/CT-guided biopsy finds application in the evaluation of liver lesions, among others. The indication for this procedure should be individualized and taken into account the level of suspicion of malignancy and the need for diagnostic confirmation. PET/CT-guided biopsy is feasible and may optimize the diagnostic yield of image-guided interventions.
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