Despite the various interventions to ensure that technical colleges of education graduates are well equipped with the requisite practical skills to be able to train students in the basic concept of technical education and training for the technological advancement of the country, it has not been able to transform most students at the basic level of education. The purpose of this study is mainly to assess factors affecting effective delivery of technical skills practical lessons in selected colleges of education in Ghana. A census of the tutor population of 17 was used for the study. Data was analysed using descriptive and inferential statistics and results presented in tables. The study found that, most of the facilities for practical work were non-existence, students have little experience on practical work, the factors affecting practical work were practical experience of teachers, teaching experience, age, among others. It was evident that, provision of adequate resources, exposing students to the importance of practical work and organization educative field trips to firms could be used to improve the organization of practical work in the colleges of education.