Sir:Cystic tumors of the pancreas are a heterogeneous group of neoplasms that includes epithelial tumors (benign, borderline, and malignant) and mesenchymal tumors (benign and malignant). These cystic neoplasms should be differentiated from cystic nontumoral lesions such as pancreatitis-associated pseudocysts, lymphoepithelial cysts, and other cystic lesions [6]. The most important and largest group is that of the epithelial neoplasms, which includes the most common cystic neoplasms: serous cystic neoplasms (SCNs), mucinous cystic neoplasms (MCNs), intraductal papillary-mucinous neoplasms, and solid pseudopapillary neoplasms, but also ductal adenocarcinomas and endocrine tumors with cystic features [6]. In general, SCNs are benign tumors that usually neither relapse nor metastasize and are composed of clear, glycogen-rich cells [2,6,7]. Nevertheless, MCNs are a more complex histological group comprising benign and borderline neoplasms and in situ and invasive carcinoma. In some cases of MCN, several patterns of growing or grades of malignancy may be simultaneously found, but irrespective of the histologic appearance of the epithelial component, with or without stromal invasion, pancreatic MCNs should all be considered as mucinous cystadenoma of lowgrade malignant potential [6,9].Combined cystic pancreatic neoplasms of serous-mucinous type are very infrequent, with few cases described in the English literature [1,8]. In this article we report one case of SCN, type serous microcystic adenoma (SMA), combined and intermingled with a MCN, that showed several growth patterns, and foci of invasive adenocarcinoma. We present the case of an 81-year-old woman who came to our hospital because of epigastralgia and dysphagia for the past 3 months. At the serum studies, a light increased level of cancer antigen (CEA) was present (20.2 ngr/mL) and the scanner showed a mass localized in the tail of the pancreas, with radiological features of MA. The ultrasonography and the scanner did not show diffuse or segmental cystic ectasia of the main and secondary pancreatic ducts.In July 2005, a resection of the body and tail of the pancreas was performed. The patient died 3 months thereafter due to a severe peripancreatic hemorrhage. During this time, she had been operated on again and local relapse and metastases were not found. An autopsy was not performed.The specimen of pancreatectomy showed a welldelimited mass measuring 9×7×5 cm in size with numerous tiny cysts ranging from 0.1 to 1 cm in diameter. The cysts were filled of serous fluid and surrounded by thin fibrous septa. At the periphery there was a localized, wedge-shaped stromal thickening of cicatricial appearance. The tumor was not related to the main pancreatic duct (Fig. 1). Microscopically, 70% of the tumor corresponded to a typical SMA with cysts of different sizes lined by a single layer of cuboidal or flattened epithelial cells with clear cytoplasms and central, round to oval nuclei with inconspicuous nucleoli. The stroma in between was acellular and collagenous with f...