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The appearance of wheezing sounds is widely considered by physicians as a key indicator to detect early pulmonary disorders or even the severity associated with respiratory diseases, as occurs in the case of asthma and chronic obstructive pulmonary disease. From a physician’s point of view, monophonic and polyphonic wheezing classification is still a challenging topic in biomedical signal processing since both types of wheezes are sinusoidal in nature. Unlike most of the classification algorithms in which interference caused by normal respiratory sounds is not addressed in depth, our first contribution proposes a novel Constrained Low-Rank Non-negative Matrix Factorization (CL-RNMF) approach, never applied to classification of wheezing as far as the authors’ knowledge, which incorporates several constraints (sparseness and smoothness) and a low-rank configuration to extract the wheezing spectral content, minimizing the acoustic interference from normal respiratory sounds. The second contribution automatically analyzes the harmonic structure of the energy distribution associated with the estimated wheezing spectrogram to classify the type of wheezing. Experimental results report that: (i) the proposed method outperforms the most recent and relevant state-of-the-art wheezing classification method by approximately 8% in accuracy; (ii) unlike state-of-the-art methods based on classifiers, the proposed method uses an unsupervised approach that does not require any training.

Wheezing reveals important cues that can be useful in alerting about respiratory disorders, such as Chronic Obstructive Pulmonary Disease. Early detection of wheezing through auscultation will allow the physician to be aware of the existence of the respiratory disorder in its early stage, thus minimizing the damage the disorder can cause to the subject, especially in low-income and middle-income countries. The proposed method presents an extended version of Non-negative Matrix Partial Co-Factorization (NMPCF) that eliminates most of the acoustic interference caused by normal respiratory sounds while preserving the wheezing content needed by the physician to make a reliable diagnosis of the subject’s airway status. This extension, called Informed Inter-Segment NMPCF (IIS-NMPCF), attempts to overcome the drawback of the conventional NMPCF that treats all segments of the spectrogram equally, adding greater importance for signal reconstruction of repetitive sound events to those segments where wheezing sounds have not been detected. Specifically, IIS-NMPCF is based on a bases sharing process in which inter-segment information, informed by a wheezing detection system, is incorporated into the factorization to reconstruct a more accurate modelling of normal respiratory sounds. Results demonstrate the significant improvement obtained in the wheezing sound quality by IIS-NMPCF compared to the conventional NMPCF for all the Signal-to-Noise Ratio (SNR) scenarios evaluated, specifically, an SDR, SIR and SAR improvement equals 5.8 dB, 4.9 dB and 7.5 dB evaluating a noisy scenario with SNR = −5 dB.

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