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Enantioselective syntheses Enantioselective syntheses O 0031 A Novel Enantioselective Alkylation and Its Application to the Synthesis of anAnticancer Agent. -Title investigation is presented in connection with studies on an efficient synthesis of the potent farnesyl protein transferase inhibitor lonafarnib (VI). A unique water effect on enantioselectivity and yield is observed for all alkylation reactions investigated. Other additives, e.g. LiOH, B(OH)3, MeOH or AcOH are mentioned to have no beneficial effects [most yields not given]. -(KUO, S.-C.; CHEN, F.; HOU, D.; KIM-MEADE, A.; BERNARD, C.; LIU, J.; LEVY, S.; WU*, G. G.; J. Org. Chem. 68 (2003) 12, 4984-4987; Chem. Process Dev., Schering-Plough Res. Inst., Union, NJ 07083, USA; Eng.) -Nuesgen 40-039