A vaccine inducing solely cytotoxic T lymphocytes fully prevents Zika virus infection and fetal damageGraphical abstract Highlights d Vaccine of modified ZIKV NS3 induces specific CTLs with little antibody response d The vaccine fully protects adult mice against ZIKV and greatly reduces viral titers d The vaccine protects fetuses against ZIKV challenge and reduces placental damage d Depletion of CD8+ T cells abrogates vaccine protection in animal models

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