Over time, we have come to recognize a very complex network of physiological changes enabling wound healing. An immunological process enables the body to distinguish damaged cells and begin a cleaning mechanism by separating damaged proteins and cells with matrix metalloproteinases, a complement reaction, and free radicals. A wide variety of cell functions help to rebuild new tissue, dependent on energy provision and oxygen supply. Like in an optimized “bio-reactor,” disturbance can lead to prolonged healing. One of the earliest investigated local factors is the pH of wounds, studied in close relation to the local perfusion, oxygen tension, and lactate concentration. Granulation tissue with the wrong pH can hinder fibroblast and keratinocyte division and proliferation, as well as skin graft takes. Methods for influencing the pH have been tested, such as occlusion and acidification by the topical application of acidic media. In most trials, this has not changed the wound’s pH to an acidic one, but it has reduced the strong alkalinity of deeper or chronic wounds. Energy provision is essential for all repair processes. New insights into the metabolism of cells have changed the definition of lactate from a waste product to an indispensable energy provider in normoxic and hypoxic conditions. Neovascularization depends on oxygen provision and lactate, signaling hypoxic conditions even under normoxic conditions. An appropriate pH is necessary for successful skin grafting; hypoxia can change the pH of wounds. This review describes the close interconnections between the local lactate levels, metabolism, healing mechanisms, and pH. Furthermore, it analyzes and evaluates the different possible ways to support metabolism, such as lactate enhancement and pH adjustment. The aim of wound treatment must be the optimization of all these components. Therefore, the role of lactate and its influence on wound healing in acute and chronic wounds will be assessed.

The rigorous reduction of greenhouse gas emissions in the upcoming decades is only achievable with contribution from the following strategies: production efficiency, demand reduction of energy and carbon dioxide (CO2) capture from fossil fueled power plants. Since fossil fueled power plants contribute largely to the overall global greenhouse gas emissions (> 25% [1]), it is worthwhile to capture and store the produced CO2 from those power generation processes. For natural-gas-fired power plants, post-combustion CO2 capture is the most mature technology for low emissions power plants. The capture of CO2 is achieved by chemical absorption of CO2 from the exhaust gas of the power plant. Compared to coal fired power plants, an advantage of applying CO2 capture to a natural-gas-fired combined cycle power plant (CCPP) is that the reference cycle (without CO2 capture) achieves a high net efficiency. This far outweighs the drawback of the lower CO2 concentration in the exhaust. Flue Gas Recirculation (FGR) means that flue gas after the HRSG is partially cooled down and then fed back to the GT intake. In this context FGR is beneficial because the concentration of CO2 can be significantly increased, the volumetric flow to the CO2 capture unit will be reduced, and the overall performance of the CCPP with CO2 capture is increased. In this work the impact of FGR on both the Gas Turbine (GT) and the Combined Cycle Power Plant (CCPP) is investigated and analyzed. In addition, the impact of FGR for a CCPP with and without CO2 capture is investigated. The fraction of flue gas that is recirculated back to the GT, need further to be cooled, before it is mixed with ambient air. Sensitivity studies on flue gas recirculation ratio and temperature are conducted. Both parameters affect the GT with respect to change in composition of working fluid, the relative humidity at the compressor inlet, and the impact on overall performance on both GT and CCPP. The conditions at the inlet of the compressor also determine how the GT and water/steam cycle are impacted separately due to FGR. For the combustion system the air/fuel-ratio (AFR) is an important parameter to show the impact of FGR on the combustion process. The AFR indicates how close the combustion process operates to stoichiometric (or technical) limit for complete combustion. The lower the AFR, the closer operates the combustion process to the stoichiometric limit. Furthermore, the impact on existing operational limitations and the operational behavior in general are investigated and discussed in context of an operation concept for a GT with FGR.

: Over time, we have come to recognize a very complex network of physiological changes enabling wound healing. An immunological process enables the body to distinguish damaged cells and begin a cleaning mechanism by separating damaged proteins and cells with matrix metallopro-teinases, a complement reaction, and free radicals. A wide variety of cell functions help to rebuild new tissue, dependent on energy provision and oxygen supply. Like in an optimized "biorector," disturbance can lead to prolonged healing. One of the earliest investigated local factors is the pH of wounds, studied in close relation to the local perfusion, oxygen tension, and lactate concentration. Granulation tissue with the wrong pH can hinder fibroblast and keratinocyte division and pro-liferation, as well as skin graft takes. Methods for influencing the pH have been tested, such as occlusion and acidification by the topical application of acidic media. In most trials, this has not changed the wound's pH to an acidic one, but it has reduced the strong alkalinity of deeper or chronic wound. Energy provision is essential for all repair processes. New insights into the metabolism of cells have changed the definition of lactate from a waste product to an indispensable energy provider in normoxic and hypoxic conditions. Neovascularization depends on oxygen provision and lactate, signaling hypoxic conditions even under normoxic conditions. An appropriate pH is necessary for successful skin grafting; hypoxia can change the pH of wounds. This review describes the close interconnections between the local lactate levels, metabolism, healing mechanisms, and pH. Furthermore, it analyzes and evaluates the different possible ways to support metabolism, such as lactate enhancement and pH adjustment. The aim of wound treatment must be the optimization of all these components. Therefore, the role of lactate and its influence on wound healing in acute and chronic wounds will be assessed.

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