A novel iodide-catalyzed reduction method using hypophosphorous and/or phosphorus acids was developed to reduce both diaryl ketones and nitroarenes chemoselectively in the presence of chloro and bromo substituents in high yield. This efficient and practical method has been successfully applied to a large scale production of a potential anticancer agent.

Exergames, video game systems that require exertion and interaction, have been rising in popularity in the past years. However, research on popular exergames shows mixed health benefits, potentially due to minimal energy expenditure and decreasing use over time. This paper presents a 2x2 experimental study (N = 44), using a popular exergame, where we vary the framing of intention (i.e., "Gameplay" or "Exercise") and feedback (i.e., "Health" or "No health") to explore their single and interactive impacts on perceived exertion, objectively measured energy expenditure, affect, and duration of usage in a single session. Our study showed that participants primed with exercise used the system significantly longer than those primed with game play (M = 49.2 ±2.0 min versus M = 39.3 ±2.0 min). We discuss our results and possible design implications based on our single-session experiment. We conclude with a discussion on the potential impact of focusing on "healthifying" exergames-highlighting an exergames' dual purpose as both a game and exercise-as opposed to gamifying health behaviors.

The method is effective to reduce various nitroaromatic compounds to the corresponding anilines. The reaction proceeds mostly chemoselectively but dehalogenation takes place for substrates (III) and (V). Diaryl ketones with or without nitro-groups are effectively reduced. Combination of H 3 PO 3 and H 3 PO 2 and a catalytic amount of NaI is required to achieve the synthesis of (XVI)/(XVII), building blocks for the preparation of the anticancer agent Lonafarnib (XVIII). -(WU*, G. G.; CHEN, F. X.; LAFRANCE, D.; LIU, Z.; GREENE, S. G.; WONG, Y.-S.; XIE, J.; Org. Lett. 13 (2011) 19, 5220-5223, http://dx.