Background: Dental caries is one of the most prevalent human diseases worldwide. The modern concept of minimal invasive dentistry includes early detection of incipient caries lesions and its treatment. Several optical and digital detection methods are available. Objective: This literature review presents the utility and limitations of laser fl uorescence caries detection devices DIAGNOdent (DD) and DIAGNOdent Pen (DDpen) (KaVo Dental GmbH, Biberach/ Riβ, Germany) for carious lesions on the occlusal surfaces of the permanent dentition. Data sources: All available in vitro and in vivo studies from Google Scholar, PubMed and Scopus machines corresponding to caries, DIAGNOdent, DIAGNOdent Pen and laser fl uorescence as key words, were reviewed. Data extraction: Certain limitations of the studies were the inadequate analysis of the experimental protocols, the widespread sample use of the third molar, mistakes in sample handling and the limited number of studies evaluating the detection capability of DD and DDPen for secondary caries. Data synthesis: DD and DDPen are useful devices for caries detection on the occlusal tooth surfaces. Their main advantages are the very high reproducibility of measurements (>0.90), the ease of handling and the quantifi cation and monitoring capacity. Their main limitations are the relatively low specifi city for enamel lesions, the necessity of unstained surfaces and absence of plaque and pastes during measurements and the absence of a universal, clinically functional calibration value (COV). Conclusion: Further studies are required for more reliable data analysis and clinical interpretation of the relevant results. Keywords: caries, DIAGNOdent, DIAGNOdent Pen, laser fl uorescence, laser.