Field studies in the Romanian South Carpathians (longitude 22.5° to 24.2°E and latitude 45.2° to 45.6°N) demonstrate (1) Cretaceous top‐to‐NE shearing parallel to the present strike of the thrust system connected with coaxial flattening within the generally northwest dipping foliation, (2) Paleogene ductile‐brittle dextral wrenching, E‐W compression (σ1: 87±15°), and basin formation (Petroşani basin) along the Cerna‐Jiu fault system, (3) large‐scale Miocene dextral wrenching along the northern margin of Moesia (σ1: 143±16°), and (4) probably Pliocene–early Pleistocene N‐S compression (σ1: 205±25°). We discuss the tectonics of the South Carpathians stressing the corner effect of the Moesian foreland promontory during convergence and formation of the Carpathian orocline. Up to the late Early Cretaceous, subduction of oceanic crust was active between Europe‐Moesia on one side and East Carpathia‐Rhodopia on the other side. Collision and intracontinental deformation occurred during the late Early and Late Cretaceous. The pinning of the thrust front at the western tip of Moesia and the foreland recess north of it caused superposition of thrusting and wrenching during collision and lateral translation, tangential stretching during orocline formation, and spreading into the recess. Further convergence during the early Tertiary resulted in dislocation of the previously welded East Carpathian‐Rhodopian and Moesian fragments along the Cerna‐Jiu fault system and the further northeast translation of the western segment. The intramontane Petroşani basin opened as a northeasterly propagating, transient pull‐apart structure along the Cerna‐Jiu fault system, which acquired a curved, northwesterly convex, transtensional trace due to the shape of the Moesian promontory. Tightening of the Carpathian orocline and/or rearrangement of the microplate geometry during the formation of the Pannonian basin system led to large‐scale dextral wrenching along the northern margin of Moesia. Pliocene N‐S compression reflects final shortening in the Carpathian system before ongoing convergence between Europe and Africa was transferred to the Mediterranean. Rotation of material lines around the Moesian corner is corroborated by paleomagnetic studies.

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We analyzed whether a low pretreatment hemoglobin level is a prognostic factor in endometrial cancer and whether it is associated with thrombocytosis. Two hundred and twelve patients with endometrial cancer treated with surgery were reviewed. Data were analyzed with Pearson's chi-squared test, Fisher's exact test in contingency tables, the Mann-Whitney U-test, the Student's t-test, and Kaplan-Meier estimates. Multivariate analysis was performed with the log-rank test and the Cox proportional hazard model. Thirty-nine patients (18%) had a pretreatment hemoglobin value of < 12.0 g/dL. These 39 patients had significantly higher rates of nonendometrioid histology, high-grade tumors, myometrial invasion of > 50%, adnexal involvement, lymph-vascular space involvement, and advanced FIGO stage than patients with hemoglobin > or = 12.0 g/dL. The rate of thrombocytosis was significantly higher in patients with a low hemoglobin level (36% vs. 8%, P < 0.01). The overall 5-year survival rate of patients with low pretreatment hemoglobin was 59% compared with 89% for those with hemoglobin > or = 12 g/dL (P < 0.01). In the multivariate analysis age, thrombocytosis, nonendometrioid histology, high-grade histology, and advanced FIGO stage were significantly associated with a poor prognosis whereas adnexal involvement, lymph-vascular space involvement, low hemoglobin and myometrial invasion were not. These data indicate that low pretreatment hemoglobin is a prognostic factor in patients with endometrial cancer and that it is associated with thrombocytosis. Low hemoglobin was strongly associated with other unfavorable prognostic factors so that it was significant in the univariate but not the multivariate analysis.

In this paper we introduce the concept of ‘islands of sustainability’. The basic assumption is that the development towards sustainability can be introduced starting from sustainable islands'. An island is an area where sustainability is reached at a local or regional level. Exchange activities within the regional network and with the environment are key points in creating an island of sustainability. One of the main theses is that the concept of sustainability addresses not only the interactions between the economic system and the ecosphere, but also structural aspects of the anthropogenic system, such as the economic diversity and economic connectedness. Hence, sustainability is linked to the complexity of the regional network. In order to attain sustainability the intensity, the speed, and comprehensiveness of internal and external interactions, as well as the connectedness of the regional network, have to be changed. In this paper we examine the regional system. The structure, elements, interactions, and boundaries of the regional system are discussed in detail. This systems analysis is the basis of the definition of islands of sustainability. Once we reach sustainable development within islands, we then turn our discussion to the change of the whole unsustainable economic system. Islands of sustainability can be seen as ‘troublemakers’ which infiltrate the whole unsustainable system and act as cells of development.