The purpose of this paper was to compare the efficacy of a single dose of 3 g of fosfomycin to that of a 7-day regimen of amoxicillin-clavulanate in the treatment of asymptomatic bacteriuria during pregnancy. A randomised, prospective, interventional, analytical, longitudinal study was undertaken, in which the efficacy of two antibiotic regimens (one short and the other long) in the treatment of pregnant women with asymptomatic bacteriuria is compared. One hundred and nine patients were randomly assigned to two groups: 56 were treated with amoxicillin-clavulanate and 53 with fosfomycin. The two groups were similar in terms of co-morbidity, treatments received during pregnancy, obstetric, gynaecological and surgical history and laboratory data. The efficacy of the two regimens was similar and the eradication rate was over 80% in both groups (P = 0.720) (relative risk [RR] 1.195, 95% confidence interval [CI]: 0.451-3.165). The number of reinfections was greater in the amoxicillin-clavulanate group (P = 0.045). The secondary effects were lower in the fosfomycin group (P = 0.008). There were no significant differences in the number of persistences (P = 0.39), development of symptomatic urinary infections (P = 0.319) or recurrences (P = 0.96). Treatment with a single dose of fosfomycin is as effective as the standard course of treatment with amoxicillin-clavulanate and may be preferable due to its simpler administration and the smaller number of reinfections.

1.1. Objective: To show the results of complementary and rescue surgeries in patients with Locally Advanced Cervical Cancer (LACC), Squamous Cell Carcinoma (SCC) and Adenocar-Cinoma (ADC), with confirmation orsuspicion of tumor persistence to treatment with Chemo-Radio Therapy (CRT) with or without Intra-Cavitary Brachy Therapy (ICBT). 1.2. Material and Methods: Retrospective study of patients treated in the Oncology Service of the General Hospital of Mexico (GHM) in the period from 2008 to 2015, who had a diagnosis of Persistent Cervical Cancer (PCC) and were laparotomized in order to perform complementary or rescue surgeries. 1.3. Results: We performed 100 surgeries, 61 Complementary Hysterectomies (CH) with or without lymphadenectomy, 24 Pelvic Exenterations (PE) and 15 laparotomies because the neoplasm was unresectable. Major Complications (MC) occurred in 11/65 (16.9%) Page -01 World Journal of Medical Oncology Open Access patients treated with CRT and ICBT, and 1/20 (5.0%) of patients in the CRT group without ICBT (p = 0.2290). There was no postoperative mortality. Disease Free Survival (DFS) was 30.5 months in 66/90 (73.3%) of all patients; by surgery 51/56 (91.0%) CH and 15/19 (78.9%) PE; by histopatology, 35/56 (62.5%) with SCC and 31/34 (91.1%) with ADC (p = 0.003); and for stage II the main clinical stage with 58 patients: 22/36 (61.1%) for SCC and 20/22 (90.9%) for ADC (p = 0.0145). 1.4. Conclusions: Adyuvant surgery has a place in the management of LACC with tumor persistence or suspicion of this after conventional treatment with CRT. External Beam Radiation Therapy (EBRT) plus Chemo-Therapy (QT) plus surgery can be considered for the treatment of ADC from CS IB3.

The cholinesterase inhibitor tacrine (THA) and the M1 muscarinic agonist AF102B (cevimeline), both reported to enhance cognition in animals and humans, were tested in 5 macaques for reduction of spontaneous, random movements. Monkeys were videotaped 1 hour after administration of normal saline vehicle, after low- and high-dose intramuscular AF102B, and after low- and high-dose oral THA. Two independent blind judges counted numbers of spontaneous movements made by each monkey over 12 consecutive 15-second segments for each drug condition. Both THA and AF102B reduced movement significantly at high doses without overt side effects, warranting further research on the agitation-reducing potential of cognition-enhancing cholinomimetic drugs.

To draw attention to the increase in the frequency of endometrial cancer (CE) in recent decades and its association with overweight and obesity in a highly specialized institution. Retrospective study of patients with EC treated in the Oncology Service (OS) General Hospital of Mexico (GHM), in the years 2000 to 2017, obtaining information related to some risk factors and their classification. The data were compared with a previous study from the years 1966-1993. Of the record of 1,045 EC treated during the studied time of 44 years, 785 corresponded to the period 2000-2017 and 260 to the previous report, which meant an increase of 200% for this disease. Of gynecological cancers, the EC figures increased from 17.9% in 2010-2011 to 29.4% in 2016-2017 (p=0.0001). Overweight and obesity were in 572/785 (72.8%) of the current series vs. 120/260 (46.1%) of the previous series (p<0.05). An increase of 19% to 28% was found in women younger than 48 years when comparing the periods 2000 -2009 vs. 2010-2017 (p=0.011); 119/389 classified as stage I, (30.5%) had risk factors for tumor recurrence and 378/898 (42.0%) had advanced malignancies. An increase in CE reported in this series and its association with overweight and obesity, may highlight the public health problem that this association represents in our country.

Introducción. La enfermedad de Von Willebrand es el trastorno de la coagulación más frecuente, las manifestaciones clínicas son variables, la mayoría de las veces leves-moderadas. Objetivo. Describir las características clínicas y de laboratorio de