We tested the hypothesis that sustained, strenuous physical training alters the neuroendocrine regulatioñ f pulsatile gonadotropin and/or prolaetin seaetion in iilen. Blood was sampled at 2D-minute intervals over 8 hours in five endurance-trained men after a 10-15 mile run in the middle of the active training season, and in II nonendurance trained normal controls, In these two groups, basal patterns of physiologically pulsatile seeretion of LH, FSH, and proladin (PRL) were not significantly different in relation to the following parametersı mean serum concentration of each of the three hormones (N = ıs samplesh areas under the hormone concentration vs. time curves; fractional, incremental, md absolute pulse amplitudesı and pulse frequency, or periodicity. To test for enhanced suppressive effeds f endogenous opiates in trained male marathon mnners, subjects were administered the potent opiate-recepter antagonist, naltrexone (1 mglkg). This antagonist significantly stimulated pulsatile LH secretion by increasing mean serum LM values from 10.94 to 13.58IIlIU/ml (P = 0.007); area under the LH concentration vs. time curve increased from 5370 to 6510 mlU/ml x hours (P = 0.05) and, pulse frequency rose from 2.8 to 4.9 pulses/8 hours (P = 0.006). Naltrexone also enhanced pulse frequency of FSH secretion from 3.4 to

those of normal sedentary controls; 2) seaetion of PRL basally and in response to opiate-receptor blockade is not significantly perturbed; and 3) LH release in male athletes appears to be under tonlc inhibitory control by endogenous opiate systems, but the inhibitory influence of these opiates is not markedly exerled.

Brain noradrenergic mechanisms participate in the excitatory control of episodic LH release in many experimental animals, including the nonhuman primate. In addition, augmentation of pulsatile LH release in the rodent in response to opiate receptor antagonists is dependent upon intact central noradrenergic pathways. The applicability of these tenets to humans is not known. We tested the excitatory influence of brain noradrenergic systems on pulsatile LH secretion in normal men by administering phenoxybenzamine (an irreversible, preferentially postsynaptic, alpha 1-receptor blocker) or alpha-methyldopa (an inhibitor of brain adrenergic transmission). Five normal men underwent repetitive (every 20 min) venous sampling for 8 h to characterize episodic LH release quantitatively under basal conditions and after the administration of naltrexone, a potent opiate receptor antagonist which stimulates puslatile LH release. Subjects received saline, phenoxybenzamine (1 mg/kg, iv, over 90 min), or alpha-methyldopa (250 mg, orally, every 6 h). The following parameters of spontaneous episodic LH secretion were not altered after phenoxybenzamine or alpha-methyldopa administration: mean and integrated serum LH concentrations, LH pulse frequency, LH pulse amplitude (percentage or milliinternational units per ml increment), and absolute peak serum LH values. In addition, the administration of adrenergic inhibitors did not impede the capacity of naltrexone to significantly augment pulsatile LH secretion in these subjects. We conclude that in the doses used, phenoxybenzamine and alpha-methyldopa do not alter spontaneous or opiate-modulated episodic LH release in normal men.

The commercial success of single-integrated circuit multipliers and correlators has prompted the design of a new integrated circuit for video-speed digital convolution and correlation. This device is based on two concepts: 1.) the merging of delay and pipeline registers and 2.) "bit-slicing" the filter array in both the signal data word and coefficient dimensions. The device can update one coefficient per clock cycle. The result is an expandable "building block" which can be cascaded or paralleled to give the desired length, signal data word length, and coefficient data word length for any desired filter up to 20 MSPS.

To improve diversity in hiring, this quantitative study examines the applicant physical fitness testing standards of the Kentucky State Police (KSP) to determine whether the test or specific events have a disparate impact for female state police applicants. A sample of 427 state police applicants was collected from applicant fitness testing conducted by the KSP between 2014 and 2019. Bivariate analysis was used to compare the output of males and females. Logistic regression was used to determine predictors for passing fitness testing. The results show a potential disparate impact based upon significant performance differences in three of the five fitness events: bench press, 300-meter run, and push-ups. Predictors for passing applicant fitness testing were being male, having a lower body weight and having 2 years of military service. Sex was found to be a predictor for passing push-ups and 300-meter run. Recommendations suggest amending the fitness events, establishing equitable scoring criteria based upon sex without averaging, and reassessment and evaluation. Provisions for evaluation were provided.