One of the adverse effects that may accompany prolonged exposure to gas flaring (as with Niger Delta region of Nigeria) is increasing incidences of health anomalies amidst inhabitants. Current study investigated the effects of oil exploration and exploitation on the physical and mental health of residents of Okpai community in Ndokwa East Local Government Area of Delta State, southern Nigeria. A purposive sampling technique was used to draw a total of three hundred and forty (340) participants from the estimated population of Okpai community who have lived for a minimum of 3 years within the targeted area. Participants were then randomly recruited into three groups of equal number of interviewees of age range 18-30 (30%), 31-45 (37%) and 18-30 (33%) respectively. Majority of the respondents were in the age group of 18-30 (83%), with only 17% from 31-45 year old age group, similar to group 1. Following administration of questionnaire to participants, Socio-demographic variables were obtained after which their informed consents and approval was given. Obtained results were expressed in simple percentages, while presenting in appropriate statistical tables and graphs. Upon analysis, study observed an increase in the percentage of crude oil exploration on the physical and mental health of Okpai residents, suggesting that crude oil exploration greatly negatively affected the health status of Okpai community inhabitants. Study also established from the participants’ perception that the oil companies appeared not to be concerned or cares about the area investigated. Also from participants’ assertions, the consumption of contaminated fish and water created health problems. Participants also felt their healthcare needs were marginalized and ignored by representatives from oil companies and the local government. Most respondents described simply dealing with physical health ailments on their own or visiting their local chemist for treatments. Further studies aimed at corroborating these findings are highly recommended.