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In a previous communication (4) two of the authors (C. J. C. and J. C. K., Jr.) with Oakley studied the effect of the anhydrides of mannitol upon the dissociation constant of boric acid. Later the extraordinary potentiation of the dissociation constant of boric acid produced by a-mannitan was reported (1). Since sorbitan and isosorbide, the mono-and di-anhydrides, respectively, of sorbitol, were available for metabolic study, it was decided to determine the effect of these two compounds upon the titration curve of boric acid and to compare this with the influence of sorbitol.

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