Mesenchymal stem cells (MSCs) from post-natal bone marrow possess tremendous potential for cell-mediated gene therapy in several disease processes, and recent reports have broadened the spectrum for therapeutic applications to cancer therapy. The evidence that sites of active tumorigenesis favor the homing of exogenous MSCs have support the rationale for developing engineered MSCs as a tool to track malignant tissues and deliver anticancer agents within the tumor microenvironment. Several reports have proven the efficiency of MSCs as cell carrier for in vivo delivery of various clinically relevant anticancer factors, including cytokines, interferon, pro-drugs or replicative adenovirus, and tumor growth inhibition following engraftment within or in the vicinity of tumor. The enthusiasm for MSCs is further reinforced by the striking observation that unmodified MSCs can exert antitumorigenic activity, and preliminary reports in immunocompetent animals have provided encouraging results for the use of MSCs in cancer immunotherapy. This review highlights recent works and potential clinical applications of MSCs in this field.

Code reviews are an effective mechanism to improve software quality, but often fall short in the development of software. To improve the desirability and ease of code reviews, we introduce an approach that explores how multi-touch interfaces can support code reviews and can make them more collaborative. Our approach provides users with features to collaboratively find and investigate code smells, annotate source code and generate review reports using gesture recognition and a Microsoft Surface Table. In a preliminary evaluation, subjects generally liked the prototypical implementation of our approach for performing code review tasks. Abstract-Code reviews are an effective mechanism to improve software quality, but often fall short in the development of software. To improve the desirability and ease of code reviews, we introduce an approach that explores how multi-touch interfaces can support code reviews and can make them more collaborative. Our approach provides users with features to collaboratively find and investigate code smells, annotate source code and generate review reports using gesture recognition and a Microsoft Surface Table. In a preliminary evaluation, subjects generally liked the prototypical implementation of our approach for performing code review tasks.

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