Background: Commercial sex workers have been recognized as the high risk segment of the population since the last three decades. Though few studies have been conducted to dates in Ethiopia, all of them are focusing on the knowledge of female sex workers towards HIV/AIDS. However, no study has been done to assess the preventive practices of HIV/AIDS among female sex workers in Ethiopia as well in the study area. Therefore, this study aims to assess comprehensive knowledge and preventive practice of HIV/AIDS among female sex workers in Dessie town,
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