Background：Groundwater serves as the drinking water source, which chemical components directly affect human health. Different regions own their groundwater hydro-chemical characteristics based on various geological, hydro-geological conditions, human activities. From the perspective of human health, it is necessary to select groundwater quality health risk assessment (GQHR) factors combined with 2 hydro-chemical characteristics of different regions. Methods：In this paper, taking Tongzhou of Beijing,China as the study area, according to the groundwater hydro-chemical characteristics, NO3 -, NO2 -, NH4 + and Fwere extracted as assessment factors to evaluate the GQHR. Based on GQHR results, the formation and concentration characteristics of health risk factors and the prominent controlling role of influencing risk distribution were explored from natural and human factors. Furthermore, the targeted measures to prevent the increase of groundwater health risk were put forward. Results：Assessment factors: NO3 -, NO2and NH4 + are derived by human factors, such as sewage irrigation, fertilization, and Fstems from irrigation of geogenic high fluoride groundwater and fertilizer use. Still, their distribution is affected by natural factors (geology, geomorphology, and climate). The GQHR follows the order: children > adult females > adult males. The low and medium risk regions are located in upper groundwater, which are mainly controlled by natural factors (groundwater depth, aquifer medium, hydraulic conductivity coefficient, etc.) The measures to prevent the increase of groundwater health risk are to control the pollution sources and reduce the change of groundwater hydrodynamic conditions. The high-risk regions are located in eastern part of the study area, which are affected by both natural and human factors. The preventative measures are to reduce pollution caused by human factors and scientific groundwater resource exploitation and management.