In nature, light is one of most crucial environmental signals for developmental and physiological processes in various organisms, including filamentous fungi. We have found that both red light and blue light affect development in Monascus, influencing the processes of mycelium and spore formation, and the production of secondary metabolites such as gamma-aminobutyric acid, red pigments, monacolin K and citrinin. Additionally, we observed that the wavelength of light affects these developmental and physiological processes in different ways. These findings suggest that Monascus possesses a system for differential light response and regulation.

Versatile building blocks in the form of novel derivatives of 1,6‐anhydro‐β‐lactose have been used for the rapid and highly efficient synthesis of various proteoglycan core structures (see example). The resulting oligosaccharide–tetrapeptide conjugates can be used to investigate the mechanism of biosynthesis of glycosaminoglycans in human cartilage cells. Bn=benzyl.

Vielseitig verwendbare Derivate der 1,6‐Anhydro‐β‐lactose wurden als Bausteine für die schnelle und hoch effiziente Synthese von Proteoglycan‐Kernstrukturen genutzt (siehe Schema). Die gebildeten Oligosaccharid‐Tetrapeptid‐Konjugate können eingesetzt werden, um den Mechanismus der Glycosaminoglycan‐Biosynthese in menschlichen Knorpelzellen zu untersuchen. Bn=Benzyl.

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