Dengue is an arthropod-borne flavivirus associated with hemorrhagic fever and hemorrhagic shock. Roughly one third of the world population lives at risk of dengue infection, and it is not possible to accurately predict which patients are at risk for severe or fatal infection. Currently, there is no treatment for dengue infection. However, several classes of agents are in under investigation as potential anti-dengue drugs, including direct antivirals, host modulators, and RNAi therapeutics. These anti-dengue drugs in development will be reviewed here.