Background and Objective: Cardiovascular disease is the leading cause of morbidity and mortality in diabetic patients. The objective of this study was to determine the frequency of diabetic patients with a serum BNP level greater than 100 pg / ml and to establish the relationship between BNP and other variables. Methods: This is a cross-sectional study carried out in 50 diabetic patients admitted to the metabolic diseases department of the University Hospital of Brazzaville between May and October 2018. Results: A single type 2 diabetic patient presented a BNP = 187.4 pg / ml, a frequency of 2%. BNP level was associated with age (p = 0.005) and creatinine (p = 0.003). The small number of samples and an untargeted population did not allow us to profile BNP in diabetic patients. Conclusion: the mean BNP is high in diabetics in Congo Brazzaville despite a small sample size which does not allow the results to be generalized.

Objectives: Our goal was to contribute to the production of reference values ​​of plasma or serum biochemical markers by determining the reference values ​​of gamma-glutamyltransferase (GGT), aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) in young Congolese presumed to be healthy. Methods: 250 young Congolese presumed to be healthy (125 boys and 125 girls) aged 15 to 25 participated in the study. They were selected according to anamnestic and clinico-biological criteria. Samples were taken on a tube containing EDTA and the resulting plasma was stored at -20 ° C. The KENZA MAX spectrophotometer was used to analyze GGT, ASAT and ALAT. The median and the 2.5-97.5 percentiles were used to set the reference limits for each enzyme. The benchmarks determined were compared with those reported by other Africans, Europeans, Indians and Americans. Results: The established reference values ​​were: GGT 12.15-61.85 IU/L for boys and 7-51.95 IU / l for girls (p˂0.0001); ASAT 21.60-94.85 IU/L for boys and 17-84.85 IU/L for girls (p = 0.0003); ALAT 8.30-74.40 IU/L for boys and 8-53.85 IU/L for girls (p˂0.0001). In addition, the comparison between our values ​​and those of other populations showed significant differences. Conclusion: Our results underline the importance of establishing reference values ​​for plasma enzymes specific to the Congolese population. The use of the values ​​established in the ’other populations could induce errors of judgment by excess or by default. Key words: Gamma-glutamyltransferase, Aspartate aminotransferase, Alanine aminotransferase, Reference values, Congo.