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Synthesis and Biological Activity of 1,3-Dimethyl-6-nitro-7carboxyalkyl(aryl)aminopyrido(2,3-d)pyrimidines.-By reaction of 1,3-dimethyl-6-nitro-7-chloropyrido(2,3-d)pyrimidin-2,4, 5-trione (I) with aliphatic amino acids (IIa) -(IId), anthranilic acid (IIe), and its ester (IIf), the title compounds (III) are obtained. Starting with (III), some new derivatives are prepared, e.g. the pyrimidopyridodiazepine (VII) and (XII), as outlined in the reaction scheme. Reaction of the γ-amino acid (IIIc) with SOCl2 yields the lactam (VIII) which is hydrogenated and subsequently treated with PPA to give the pyrroloimidazopyridopyrimidine (X). The antitumor activity of some of the compounds obtained is tested. -(BYSTRYAKOVA, I. D.; LOSEV, G. A.; SAFONOVA, T. S.; Khim.-Farm. Zh. 26 (1992) 1, 48-51; NIKhFI, Novokuznetsk; RU)

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