Introduction: Non-anatomical resections of liver tumors are becoming more popular because they spare a larger portion of healthy liver parenchyma. However, the lack of anatomical landmarks to follow during the resection process makes them technically more challenging than anatomical resections. Image-guidance systems have been introduced to provide additional guidance, but are rarely used due to their inaccuracy, time-effort and complexity in usage and setup. Therefore, we have designed a new navigation approach that renders a surgical plan intra-operatively in real time using only navigated ultrasound. Method: The ultrasound based navigation approach comprises the following steps:

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