This study was carried out to evaluate the efficacy of water soluble formulation of diclazuril (1%) in the prevention and control of mixed Eimeria infection in two experimental (semifield) trials and testing efficacy of this medicament in controlling of natural field case of mixed Eimeria infection. The experimental (semifield) trials carried out each on 150-day-old broiler chicks, as they were divided into 3 equal separate subgroups. Infected groups were orally received 1ml of an inoculum containing 50.000 sporulated oocysts of Eimeria tenella, E. acervulina and E. necatrix/ chick at 14 days of age. Diclazuril (1%) liquid at dose of 1 ml / 4 liter of drinking water for 2 successive days just after appearance of bloody dropping (at the 5 th day post infection). Birds were given prophylactic diclazuril dose (1 ml / 8 liter) at the 7 th day before the experimental inoculation. In both trials were oocyst count (shedding) in the dropping, dropping score, lesion score, body weight gain % and mortality rate were evaluated. Groups treated with diclazuril either in the prophylactic and curative studies gave significant and satisfactory improvement in the assessment criteria when compared with infected non medicated groups.A field trial was conducted 2 commercial broiler chicken farm consisted of 2 flocks aged 33 days; 6000 birds each. Flock (1) was kept as control positive infected non medicated group, whereas flock (2) was medicated with diclazuril (1%) at dose of 1 ml / 4 liter of the drinking water for 2 successive days. The results revealed more reduction in total oocyst count, lesion score and the mortality rate in the medicated than the infected non-treated group. The results proved that diclazuril (1%) liquid is effective in prevention and control of both experimental and field infection field circulating Eimeria species still sensitive to the drug. ef Su -Beni Veterinary Medical ِ Journal

In 9 weeks field study, a total of 14100 (Ross broiler breeders) 51 weeks-old chickens fed on the same ration, placed in 2 houses (6600 female + 450 male / house). Birds of house 1 were treated with antimycotoxin adsorbent aluminum silicate (G-V-tox®) 5 kgm/ ton, while those of house 2 were kept as non treated controls. Productivity and reproductivety parameters were calculated for comparison. Treated flock showed improved average egg production (Average 62.2%/week) compared with non treated (Average 61.7%/week), but all still lower than farm stander (Average 76.4%/week). Marked improvement was in the 1 st 3 weeks (51-53) of treatment only. Total 9 weeks production declined was 5.5% and 8.4% in control and silicate treated flock; with weekly average of 0.61, and 0.93; respectively. Control flock was slower in decline of production (0.61%/week) than treated flock (0.93%/week). Average weekly egg production and hatching eggs/ hen in treated flock was lower than standard and higher than non treated. Hatchery parameters of treated were improved in treated at the first 3 weeks post treatment. The fertility was higher in aluminum silicate treated group (77.2%), than the untreated one (72.19%). The hatchability was in silicate treated (63.66%) versus (62.25%) in the untreated control. Culls % in hatched chicks was 1.91% in treated flock and lower than in non treated (2.85%). Difference percentage between fertility and hatchability of G.V. tox treated chickens was (10.84%) higher than untreated control (16%). The number of marketable chicks l100 was also improved in treated than non treated. In conclusion, our field study cleared that administration of Silicate in ration for treatment of broiler breeders resulted in an improved production and hatchery performance as compared with non medicated control. However; it did not restore it to the farm stander. Consequently the results indicated that we still in need for more effective products to be used to control mycotoxins in breeder chicken.

The purpose of the assignment is to provide technical assistance to support the preparation /strengthening of the currently drafted Integrated National Planning for disease prevention, requirement from poultry products and required improvements for future. The obtained data here were collected from site visits and interviews with project owner as well as official documents and reports.

This study was carried out on serum samples collected from broiler breeder chicken flocks vaccinated with avian influenza (AI) H5N1 inactivated vaccine. These flocks included 23 flocks aged 13 to 47 weeks reared in close houses in 7 sites; two vaccinated breeder flocks for HI antibody monitoring by 5 weeks interval samples and 8 flocks aged 41 weeks reared in different sites with identified females and males samples. The vaccine was used in a dose of 0.2 ml at 1 day in hatchery and revaccinated with 0.5 ml at age of 18 days, 19-20 weeks and 40 weeks. Hemagglutination inhibition (HI) test was carried out against homologous antigen.The study pointed out that AI H5N1 inactivated vaccine under field application induced irregular and low HI titres following the 1 st two doses ranged from log 2 0.0 to 4.15 with great variation between flocks, where samples with titre 0-2 ranged from 20 to 100%. The 3 rd dose at 19-20 weeks was essential to elevate HI titres 3.25 to 7.44 with more homogenizes flock immunity and lower percentage of titres 0-2 ( 0-20 %) and as measured by HI test. Revaccination of layer flocks at 40 weeks (fourth dose) improves flock immunity facing stress of egg production as evaluated by HI (5.52 -6.33) and lower negative percentage (5.5-11.7%). Monitoring of breeder flock every 5 weeks is essential to detect proper time of revaccination as each flock has its HI antibody curve. There was a difference in HI tit re rang log 2 0.33 to 1.2 between male and female chicks reared in the same house, but this variation not affecting flock mean.Birds at aged 41 weeks having titres < log 2 3 (Seronegative) were protected when exposed to contact with infected flock as showed no clinical signs or change in HI titres after 12 days.In conclusion the usage of homologous inactivated H5N1 vaccine in 4 doses in layer flocks was of value in improving chicken immunity to AI H5N1 wild strain circulate in our field.

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