A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Oxidative stress has been well recognized as a component in the pathogenesis of many diseases, including female infertility. In this study, we aimed to investigate serum paraoxonase (PON1), arylesterase and myeloperoxidase (MPO) activities, and lipid hydroperoxide (LOOH) levels as oxidative stress markers along with their relationship with the pregnancy rate in women undergoing in vitro fertilization (IVF) treatment. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Serum samples of 179 subjects were collected immediately before starting ovarian stimulation and on ovum pick-up (OPU) day during IVF treatment. Stimulation protocol and starting doses were determined individually. When the leading follicle reached at least 17 mm in size, recombinant human chorionic gonadotropin (Ovitrelle, 250 mcg, Serono) was administered for ovulation induction. Serum basal/salt-stimulated paraoxonase, arylesterase activities, myeloperoxidase activity, and lipid hydroperoxide levels were compared between two samples. Subjects were also divided into two groups according to the presence of pregnancy, and the groups were compared in terms of oxidative stress markers studied. R Re es su ul lt ts s: : Serum MPO activity and LOOH levels were significantly higher on ovum pick up day (p<0.05, p<0.001, respectively), while basal/salt-stimulated paraoxonase and arylesterase activities were significantly lower (p=0.012, p=0.041, respectively) than those before ovarian stimulation. Serum LOOH levels on OPU day were significantly higher in non-pregnant group than pregnant one (p<0.001). Although basal/salt-stimulated paraoxonase, arylesterase and myeloperoxidase activities were higher in the non-pregnant group compared to the pregnant group, it was not statistically significant (p>0.05). C Co on nc cl lu us si io on n: : Ovarian stimulation during IVF treatment resulted in increased oxidative stress and decreased PON1 activity. However, changes in the studied parameters were not found to be significantly associated with the pregnancy results. Further studies are required to clarify our results.K Ke ey y W Wo or rd ds s: : In vitro fertilization; lipid peroxides; peroxidase; PON1 protein, human Ö ÖZ ZE ET T A Am ma aç ç: : Oksidatif stresin, kadın infertilitesi de dahil olmak üzere bir çok hastalığın patogenezinde yer aldığı gösterilmiştir. Bu çalışmada, in vitro fertilizasyon (IVF) tedavisi uygulanan kadın-larda oksidatif stres belirteçlerinden serum paraoksonaz (PON1), myeloperoksidaz (MPO), aril esteraz aktiviteleri ile lipid hidroksiperoksid (LOOH) düzeylerini ve bu belirteçlerin gebelik oranlarıyla ilişkisini araştırmayı amaçladık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Yüz yetmiş dokuz olgunun serum örnekleri ovaryan stimulasyona başlanmadan hemen önce ve tedavi esnasında yumurta toplama günü (OPU) alındı. Stimulasyon protokolü ve başlangıç dozları bireysel olarak belirlendi. Dominant folikül boyutu en az 17 mm'ye ulaştığında, ovulasyonu tetiklemek için reko...

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