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ForumI I27 ties sometimes showed BP rises which were interpreted initially as reflecting the adequacy of resuscitation and later as indicating the requirement for further analgesia during surgery.Vomiting was not a postoperative problem with these TSA techniques. Jaundice was not detected in those patients receiving repeated halothane anaesthetics, nor in those receiving group compatible blood transfusions; no haemolytic reaction was precipitated nor was any infection transmitted by this transfusion technique.The results obtained with the TSA were considered to be satisfactory and suggest that the TSA is reliable, simple to use, versatile and safe for all age groups and all types of surgery. AcknowledgmentsThe authors wish to thank Brigadier C.D. Sanders QHS for his help and guidance in the preparation of this report.

The effects of Org NC 45 and pancuronium bromide on heart rate and arterial pressure were studied in anaesthetized man. A bolus of either Org NC 45 0.1 mg kg-1 or pancuronium 0.1 mg kg-1 was administered to lightly anaesthetized unstimulated subjects. Following Org NC 45 heart rate decreased in the majority of subjects (mean and SEM 3.78 +/- 1.36), whereas after pancuronium heart rate was increased (mean and SEM 11.91 +/- 1.9). The changes in mean arterial pressure observed were minimal. The effect of endotracheal intubation on mean arterial pressure was then studied. Increase of mean arterial pressure was observed in all subjects. The increase was more marked in those patients who had received pancuronium and was significantly higher than in those patients who had received Org NC 45 (P less than 0.01). We conclude that Org NC 45 is devoid of vagal blocking action, and that the difference in response to the stimulus of endotracheal intubation is a result of the different effects exerted on the sympathetic nervous system by Org NC 45 and pancuronium.

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