SUMMARY An cctosylvian spiking focus, induced by topical application of mescaline, brought about changes in nitrogenous compounds not only in the focus but throughout the cerebral cortex. Prior to the onset of the spiking focus, 2 min after mescaline application, ammonia levels increased significantly in all neocortical areas, especially at the focus and homolateral marginal gyrus; free amide nitrogen decreased and non‐protein nitrogen increased throughout the cortex. During the development of the focus–at 30 min–the ammonia level still remained high, with a tendency to decrease, and free amide nitrogen was decreased in all neocortical areas. A decrease in‘protein nitrogen’in marginal gyri, on either side and in lipid nitrogen in the epileptical focus as well as in both marginal gyri was also noted.

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