ABSTRACT

Lymphoma is the most frequent hematopoietic neoplasm in dog, and it shares some clinical, cytological, histopathological and molecular similarities with humans. In our study, DNA changes in TP53, c-KIT and N-RAS were detected in lymphoma tissues of cross breed bitch and Bernese Mountain Dog bitch. One transition A/G at nucleotide position 138 in exon 5 in TP53 gene and one transition G/A at nucleotide position 35 in exon 8 of c-KIT gene were observed in donor 2. It seems that these genes did not play a key role in canine lymphoma formation and progression.