3 fi, 10-HJMetergoline (9) has been prepared starting from 1-methyllysergamide (5) which was reduced with tritium gas to 1-methyl-fi, 1 0-3H]dihydrolysergamide. ted to 2 in two steps with a 42% overall radiochemical yield.[ G 3 H ] and 6 7 -HJnicergoline were prepared starting from generally labelled fi and from 2 respectively. The latter was obtained by reducing the ester (13) with sodium borol3H2hydride. Similarly, l-demethyl-fi7-HJnicergoline (=) was also obtained. & m b~l -~~C 2 5-bromonicotinic acid (2) was prepared from K14CN y & 3-L-l 4CJcyanopyridine (16) which was converted into 17 and Einally brominated. nicergoline (z) was obtained by condensation of 2 and 2.Radiochemical yield of l5, 1 & , and 15b from 3 and was approximately 4osC after the chromatographic purification step.