The word "apoptosis" was misspelled in the title, in the fourth sentence of the Abstract, in the first sentence of the third paragraph of the Introduction, and in the abbreviations list in Footnotes. The error has been corrected in the online version, which now differs from the print version as originally published. In Results and Discussion, after the first sentence in the last paragraph, the authors wish to add the sentences shown below. In References, the authors also wish to add the citation shown below.Recently, Bielekova et al. described their findings concerning the induction of CD56 bright NK cells by anti-IL2R therapy in multiple sclerosis patients (31). This is consistent with our observations in uveitis patients.
In this review, we first revisit the original concept of “suppressor T-cells” in pregnancy, put it in a historical perspective, and then highlight the main data that licensed its resurrection and revision into the concept of “regulatory T-cells” (Tregs) in pregnancy. We review the evidence for a major role of Tregs in murine and human pregnancy and discuss Treg interactions with dendritic and uterine natural killer cells, other players of maternal–fetal tolerance. Finally, we highlight what we consider as the most important questions in the field.
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