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Mesoporous Al-SBA-15 with different Si/Al molar ratio (10, 20, 30, and 40) was synthesized hydrothermally, and Mo–Ni catalysts were prepared by incipient wet impregnation method and characterized by different techniques. An impressive catalytic performance was observed on Mo–Ni/Al-SBA-15(10) for Methylcyclohexylamine conversion to hydrocarbons. The observed trend of activity is correlated with the aluminum content, and it is concluded that the variation in Si/Al ratio remarkably affects the hydrodenitrogenation ability of Al-SBA-15 supported Mo–Ni catalysts.

A variety of novel 3-(3-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-(3-methylphenyl)-3H-quinazolin-4-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(3-methylphenyl)-3H-quinazolin-4-one was synthesized from 3-methyl aniline. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. Compound 2-(1-ethylpropylidene-hydrazino)-3-(3-methylphenyl)-3H-quinazolin-4-one (AS2) was the most active analgesic agent. Compound 2-(1-methylbutylidene-hydrazino)-3-(3-methylphenyl)-3H-quinazolin-4-one (AS3) was the most active anti-inflammatory agent and was moderately more potent than the reference standard diclofenac sodium. The test compounds showed only mild ulcerogenic potential compared with aspirin.

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