KEYWORDS Laurus nobilis Biochemical markers CCl4Hystochemistry Toxic hepatitis ABSTRACTIn present study effect of laurel leaf extract (Laurus nobilis) on biochemical parameters and histomorphology of rat liver induced by toxic damage of CCl4 was studied. Introduction of CCl4 in animals was always carried out in fatal to 36 hours. A single injection of the L. nobilis extract ssimultaneously with CCl4 leads to 100% survivability. To evaluate the degree of hepatocyte damage in experimental modeling hepatitis de Ritis index was used. It has been reported that intraperitoneal injection of a lethal dose of CCl4 activates hepatocyte damage in the key markers, such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, γ -glutamiltransferase, bilirubin, urea, albumin, glucose, cholesterol, triacylglycerides. Simultaneous treatment of CCl4 with Laurus nobilis leaves extract prevented death and exhibit a normalizing effect on the main indicators of liver damage and index de-Ritis. Result of the present study revealed that L. nobilis extract have capacity to manage metabolic and histological abnormalities of hepatocytes toxic damage induced by CCl4.