Background and Purpose: The development of vaccines against the SARS-CoV-2 virus has become a big challenge for many countries in 2020-2022. mRNA vaccines were shown to be effective and safe and have been widely used worldwide in the fight against the COVID-19 pandemic. The fundamental factor in creating mRNA vaccines, which ensures effective delivery of mRNA to the host cells, is the composition of lipid nanoparticles, namely the presence of ionized charged lipids, which ensures the binding of mRNA molecules. However, the significant role of liposomes in the development of liposomal vaccines and identification of immunochemical reactions involving lipids should be assessed in the context of the development of the pioneering idea of August Wassermann about the use of liposomal antigens in the diagnosis and immunoprophylaxis of serious human diseases. Experimental Approach: The review is devoted to the use of liposomal antigens as antigen-delivery systems for diagnosis and immunoprophylaxis. Key  Results: Studies of cardiolipin antigen in serodiagnosis of syphilis became the foundation of antibodies in diagnosing various infectious diseases and pathological conditions, such as tuberculosis, lupus erythematosus, COVID-19, borreliosis, etc. Identification of antiphospholipid antibodies (mainly anticardiolipin) and today is the most important diagnostic tool for antiphospholipid syndrome. Conclusion: The liposomal system first proposed in 1906 for the diagnosis of syphilis evolved more than a century later into mRNA vaccines, which are used today in the fight against the COVID-19 pandemic.

Purpose: checking the assimilation of beta-carotene from a nanostructured globe and the influence of nanostructured beta-carotene 10% on productivity and organoleptic qualities of products.Materials and methods. Experience was conducted on the basis of the Russian Pularka farm "Russian Pularia" of the Leningrad Region. 2 groups of the quail of meat - the egg direction of the Estonian breed were formed for 10 goals at the age of 50 days - the beginning of egg production. All groups of quails were contained in the same conditions, all the parameters of the microclimate in the premises, the front of feeding and post corresponded to the recommended standards. Egg productivity was evaluated in accordance with GOST 27583- 88 in the context of groups: the mass and number of eggs were determined by loafer; Color of the yolk on the Rosh scale; The content of vitamin A and beta-carotene in the yolk. The experience included three stages: 1st day-the implementation of landing quail quails; 2-10 days - the adaptation of the bird to new conditions of content; 11-20 days - directly the accounting period of experience. Feeding the control group was carried out by standard compound feed PC 1-1 of the production of the Gatchinsk compound factory. For an experimental group, a mixture of feed PC 1-1 was prepared with the addition of nanostructured beta-carotene 10%. 1 group (control) - PC 1-1 food at the rate of 30 g/head. Group 2 (experimental)-PC 1-1 food at the rate of 30 g/head + 36 mg of nanostructured beta-carotene 10% (at the rate of 150 mg/kg of poultry mass). The number and weight of the eggs of each group was fixed daily in the journal. Eggs of the experimental and control groups were stored separately.Results. IResults. The fodder forms of beta-carotene are not economically impractical, especially with industrial breeding of a bird. In our work, we studied the introduction of a polymer complex of a nanostructured form of B-carotene into the production of a polymer complex, which is unique. It forms complex emulsions with fat -soluble vitamins, which can be considered as a nano. The studies have shown that the intensity of the color of the yolks of the eggs of the experimental group was significantly higher than this indicator of the control group, which shows the bio-converters of the β-carotene in the yolk of the egg. At the same time, the masses of eggs in the experimental group were higher, but this excess was small.