No abstract

Background Mycoplasma hyopneumoniae (Mhyo) and Porcine circovirus 2 (PCV-2) are two of the most significant infectious agents causing economic losses in the weaning to slaughter period. Due to their similar vaccination age, the objective of this study was to assess the efficacy of two already existing Mhyo (Hyogen®) and PCV-2 (Circovac®) vaccines when administered separately or combined (RTM) by means of Mhyo or PCV-2 experimental challenges. Results Seven groups of animals were included in the study, being three of them challenged with PCV-2, three with Mhyo and one composed of non-challenged, non-vaccinated pigs. Within each experimental challenge, non-vaccinated (NV) groups were compared with double vaccinated groups using the commercial products separated (VS) or combined (VC). Both vaccinated groups showed significant differences for most parameters measured regarding PCV-2 (serology, percentage of infected animals and viral load in tissues) and Mhyo (serology and gross lesions) when compared to NV groups. VS and VC offered similar results, being only significantly different the PCV-2 antibody values at different time points (higher in the VS group) of the study, although not at the termination day (21 days post-PCV-2 inoculation). Conclusion The present study expands the knowledge on the possibility of using two separate Mhyo and PCV-2 commercial vaccines as a RTM product, which offered equivalent virological, immunological and pathological outcomes as compared to these vaccines when used by separate.

A study performed on Peruvian children < 10 years of age and their controls showed that Campylobacter jejuni is a leading cause of diarrhoea. Infants 1 year old or younger were the most affected. The disease was usually moderately severe, although > 50 per cent of patients required i.v. fluid therapy. Campylobacter was also more frequent in malnourished patients, who come from socio-economically deprived groups, with overcrowding, poor sanitation, and frequent contact with domestic birds and animals. The seasonal behaviour suggests that diarrhoea caused by Campylobacter is endemic in this area.

A prospective study of 111 young Peruvian children with Campylobacter jejuni diarrhoea showed that it behaves as an endemic enterotoxigenic-like, waterborne, milkborne, and zoonotic disease. Although there were no definite differential features between pure C. jejuni diarrhoea, mixed-agent diarrhoea, and C. jejuni diarrhoea plus parenteral infections, children with C. jejuni diarrhoea plus parenteral infections were all inpatients, were more frequently malnourished and more frequently exhibited systemic symptoms. Campylobacter jejuni associated with other enteric pathogens did not seem to act synergistically as the disease was not particularly severe in this group.