Background: Vibrio vulntjicus, a common bacteria found in undercooked seafood and seawater, is the leading cause of food-borne death in Florida. Fatal cases of V vulntjicus infection have also been re-

The ontogeny of small intestinal glutaminase (GA) and glutamine synthetase (GS) was studied with relation to the maternal administration of dexamethasone (DEX). Pregnant Sprague-Dawley rats were administered 0.2 mg/kg of DEX or saline twice daily on days 19 and 20 of gestation. Activity of GA did not increase from the fetus to the 10-day-old rat; however, GS activity increased 7-fold. DEX induced doubling of GA activity and mRNA, but only a slight increase is GS activity and mRNA was observed in the fetus. GA and GS activities appear to be regulated by different mechanisms.

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Our trial has shown (after 200 patients) a decrease in infarct size (approximately onethird) and a reduction in the numbers developing complete infarction in those patients given intravenous beta-blockers within 12 hours of the onset of pain.' The treated group needed less diuretics both in hospital and on discharge, suggesting clinical as well as biochemical and electrophysiological benefit. It is important, as Professor Rose points out, not to dismiss (with small trials) therapy which might reduce morbidity and perhaps mortality by, say, 20% as being clinically insignificant in this common condition.