Oxidative stress is a major cause of various types of tissue damage, especially endothelial dysfunction, which occurs in diabetes mellitus. In a healthy organism the formation of ROS occurs under the strict control of the biological system, on the contrary, under severe stress, many diseases, as well as diabetes, the production of ROS increases curtly. Due to its high reactivity, an increase in the amount of SOR leads to oxidative stress, which disturb the balance between the antioxidant and prooxidant systems. The main prin-ciple of the therapeutic strategy to reduce oxidative stress in diabetes mellitus is to inhibit the formation of free radicals. The results of clinical and experimental experiments demonstrate the administration of antioxidants, especially vitamin E, insulin resistance and therapeutic effect in diabetic conditions. Recently, the use of synthetic, as well as herbal antioxidants, along with other drugs in the pharmacotherapeutic correction of a number of pathologies in medical practice has become widespread. The development of a more effective pharmacotherapeutic strategy for diabetes with antioxidants and the synthesis of potent agents are promising for further research. Key words: diabetes mellitus, antioxidant, oxidative stress, reactive oxygen species (ROS), free radicals

We have studied the glands and lymphoid structures of urinary bladder of human in sphincters zones with morphological methods on 38 preparations of different ages (from newborn till to senile period). the glands (by RD Sinelnikov method) and lymphoid structures were investigated by macro-microscopic methods after stained by Hellman method. The micro preparations incisions sphincters zones of a urinary bladder in the thickness 5-7 microns were stained with hematoxylin-eosin, by Van-Gizon, Veygert and Kreyberg methods. In the sphincters zones the glands are in close microtopographical relations with lymphoid structures (lymphoid nodules and diffuse lymph tissue) and as a rule the glands are located densely. Without dependence from age, microanatomy parameters of the glands and lymphoid structures of the sphincters zones of urinary bladder are more than in outside. Dimensional indicators at right and left ureters sphincters almost correspond. It is connected by a similar design. At senile age, lymphoid structures in sphincters of a urinary bladder are single or absent.

Borulu və boşluqlu orqanların divar elementlərinə orqandaxili sinir və damarlarla yanaşı kiçik vəzilər və limfoid törəmələr aiddir [11,13-14]. Borulu orqanların divar quruluşunun normada əldə etdiyi xüsusiyyətlər haqqında məlumat onların patomorfogenezinin qanunauyğunluqları haqqında fikir sürməyə imkan verir [14-15].  Bu tip orqanların divarında yerləşən kiçik vəzilərin və limfoid törəmələrinin morfoloji xüsusiyyətlərini əks etdirən, müasir nəzəri immunomorfologiya və morfoloji ekzokrinologiya kimi sahələrin tələblərinə cavab verə bilən nəticələr, bu orqanların müxtəlif xəstəliklərinin müalicə və profilaktikasında böyük əhəmiyyətə malikdir.

The histological methods had been studied the microanatomy peculiarities of the glands on the rats urinary bladder. Experimentally-morphological work carried out on 20 (10 rats – experiment, 10 – control) genitally mature rats-males 3-4 monthly ages, weight of a body to the experiment 180-200 gr. Histological cuts in the thickness 5-7 microns painted by hematoksilin-eozin, on Van Gizon, azur-2-eozin. After influence of the strong sulphidic procedures is observed the “morphological regression” of glands of rat’s urinary bladder, that is very much guards, considering prevalence of these procedures in practice of curortology. Course action of strong sulphidic baths of the rats leads to reduction of a thickness and the areas of alveolus, initial parts, quantity of alveolus, as well as the expansion and deformation of the excretory ducts.