Intravenous doses of 0.3 mg/kg dimethyl tubocurarine were required for consistent and adequate surgical relaxation in patients during nitrous oxide anaesthesia and produced virtually complete neuromuscular paralysis (96-100%) of the tetanic and twitch responses of the adductor pollicis muscle. The duration of action of the drug was prolonged--more than 3 h was required to attain 50% recovery from full neuromuscular paralysis. At this degree of recovery neostigmine was an effective antagonist. Determination of the tetanic tension ratios showed that tetanic fade developed during onset of paralysis and remained maximal until about 25% recovery of the tetanic contractions, when it disappeared raidly as recovery progressed. These doses caused no significant changes in arterial pressure and heart rate and this absence of cardiovascular side-effects is a desirable property of dimethyl tubocurarine. However, for many surgical procedures, an agent with a similar pharmacological profile but with a shorter action is desirable.
SUMMARY A subdural haematoma is described in which a definite computed tomographic (CT) scan diagnosis was made only after contrast enhancement had been achieved by the inhalation of xenon. The different types of enhancement obtained with iodide containing contrast media and with xenon are discussed. The use of xenon to obtain further information in conditions which are inadequately elucidated by conventional CT must be balanced against its anaesthetic effects and relatively high cost.
Purpose: Best fitting Tomotherapy treatment planning parameters for nine different lesion sites. Method and Materials: Tomotherapy treatment planning and delivery depends on parameters that are not necessarily familiar to a radiotherapy physicist. It is important for planners to familiarize themselves with these parameters and their impact on the time required for delivery: 51 Prostate plans, 268 lungs, 197 Brain, 21Liver, 38 Head & Neck, 46 Breast, 51Pelvis and 59 Pancreas plans for parameters like Pitch, Gantry period, treatment time, delivery modulation, total dose, calculated treatment length and slice width were analyzed for the best fit. Results: For Prostate average modulation delivery factor of 1.8 with average delivered dose of 51.53Gy and average treatment time of 342.4 seconds was used. Average numbers of fractions were 27. For Lung average dose of 50.70Gy with average modulation of 1.726. Average treatment time was 338.6 seconds and average numbers of fractions was 24. For Brain lesions average dose of 28.42Gy with average modulation of 1.71 was used. Average treatment time was 401.45 seconds. Average numbers of fractions was 11. For liver lesions average dose of 28.42Gy was used. Average modulation factor of 1.71 and average treatment time of 401.45 seconds. Average numbers of fractions was 11. For Head & Neck average dose of 36.08Gy with average modulation factor of 1.81 was used. Average treatment time was 420.64 seconds. Average numbers of fractions was 20. For Breast average dose of 41.44Gy with average modulation of 1.97. Average treatment time of 429.27 seconds with average numbers of fractions of 24. For Pelvis average dose of 38.8Gy with average modulation of 1.95. Average treatment time was 344.91 seconds. Average numbers of fractions was 19. For Pancreas average dose of 46.88Gy with average modulation of 1.78. Average treatment time was 266.64 seconds. Average numbers of fractions of 24.
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