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This research proposed to treat the RO rejected wastewater in a household plant by the integrated treatment system. The possibility of wellhead water treatment by the combined treatment system of coagulation and adsorption for salinity reduction via flexible high recovery RO system was evaluated through analysis of treatment options on a laboratory scale. The naturally available gooseberry seed used as a coagulant in phase-1. It reduced 99.3% of TDS and hardness. It also increases the DO level of RO reject water, at the same time it increases turbidity and color. Turbidity and color removed by surface-modified zeolite in the phase-2. The zeolite material was taken in temperature 400ºC as adsorbent of 6 cm column achieved 8NTU in 150 mmin. The 12 cm column was achieved 7.5NTU in 150 mins. Thomas and Thomson modelling well fitted with an experimental study. The regression correlation reached up to 0.942, 0.9810 and 0.984. It is apparent from the recorded SEM patterns study. This study concludes that the coagulation by Goosperry seed produced the highest removal of TDS and hardness and in the adsorption process, with 400ºC enhances the surface morphology and porous structure indicates that heating with higher-level temperature enhances the adsorption capacity of the adsorbent material. The highest efficiency is observed in hydrothermal hotness.

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Losartan is used to treat high blood pressure (hypertension) and also used to lower the risk of stroke in certain people with heart disease. Therefore, the purpose of this study is to formulate mouth dissolving tablet of losartan potassium to improve its bioavailability, to attain fast onset of action and rise patient compliance. Owing to short bioavailability of 33% and to increase onset of action, fast dissolving tablets of Losartan Potassium were formulated using coprocessed superdisintegrants in order to improve the dissolution rate, in that way the bioavailability. The effect of concentration of the Croscarmellose sodium was studied by a set of three formulations (F1, F2, F3) with concentrations of 2%, 4% and 8% w/w respectively. Similarly, the impact of Sodium Starch Glycolate was studied by a set of three formulations (F4, F5 and F6) respectively. The formulation prepared with 8% w/w of superdisintegrant showed relatively rapid release of Losartan potassium when compared with other concentrations of Croscarmellose sodium and Sodium Starch Glycolate. The formulation prepared with Croscarmellose sodium had showed relatively fast release of Losartan Potassium when compared with Sodium Starch Glycolate. Three formulations (F7, F8 and F9) were prepared by including a combination of superdisintegrants (Co-processed Mixtures), Croscarmellose sodium and Sodium Starch Glycolate by direct compression method. Formulation containing Co-processed mixtures had less disintegration time as compared to the individual superdisintegrants. Subsequently, we can conclude that nature, concentration of the superdisintegrant in addition to combination of superdisintegrants (Co-processed) showed influence on the rate of dissolution.