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This paper deals with the weight estimation of the wing box of a commercial aircraft by means of a procedure suitable for very large liners and/or unconventional configurations for which statistical data and empirical formulas may not be sufficiently reliable. Attention is focused on the need to account for aeroelastic interaction from a very preliminary stage of the design cycle. The procedure exploits the first of three levels of a multilevel structural optimization system conceived for the preliminary design of the wing primary structure and a simplified evaluation of the cross-sectional properties. The comparison between weight estimates obtained with the present procedure and predictions supplied by available literature shows a satisfactory agreement

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