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The heterotopic gastric cyst of the oral cavity is a rare lesion. A recurrent gastric cyst in the floor of the mouth of a young female patient is presented. Current theories dealing with the histogenesis of these lesions are presented and discussed. Based on the available embryologic and clinical information, a new histogenetic concept for the development of the heterotopic gastric cyst is proposed.

Ten oral verruciform xanthomas were studied using an immunoperoxidase stain for S‐100 protein. All cases exhibited positively stained dendritic cells among the mononuclear inflammatory cell infiltrate at the base of the lesions and to a lesser extent among the “foam cells”. The foam cells were, however, negative for S‐100 staining. We suggest that, based on these findings, verruciform xanthomas belong to a new category of “non‐X histiocytoses” in which the presence of Langerhans cells suggests an immunologic pathogenesis.

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Three common blue nevi from skin of the trunk and upper extremities, and 5 from oral tnucosae were studied using an itntnunoperoxidase stain for S-100 protein. The skin lesions were unifortnly negative whereas all of the oral mueosal lesions eontained nutnerous positively stained dendritie eells. This differenee may, in part, be explained by the different etnbryologic origins of the connective tissue stromas; the eontiective tissues of the head and neck are thought to be of neural crest origin whereas the eonneetive tissues in the rest of the body are of mesodennal origin. These findings strengthen and refine the assoeiation between S-lOO protein content and neural crest derivation.