Abstract. 86 sera from a Tibetan and 100 sera from a Senegalese population were typed for the factors Ag(a1), Ag(c), Ag(d), Ag(g), Ag(h), Ag(t), Ag(x), Ag(y), and Ag(z). The data are compared with results obtained from 362 sera of Swiss blood donors. The antithetical behaviour of the factors Ag(a1)–Ag(d), Ag(c)–Ag(g), Ag(x)–Ag(y), and Ag(t)–Ag(z) could be confirmed on the basis of a Hardy‐Weinberg analysis using the Tibetan and the Senegalese material. A total of 46 different Ag phenotypes was observed in the complete material. The new data were used for the evaluation of previously proposed genetic models for the Ag system. A revised model for the Ag chromosome is presented, assuming 5 closely linked loci, namely Agx/Agy, Aga1/Agd, Agc/Agg, Agt/Agz, and Agh/Ag[i]. The existence of at least 14 different haplotypes could be established, whereby some of them were observed exclusively in 1 of the 3 populations studied.

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86 sera from a Tibetan and 100 sera from a Senegalese population were typed for the factors Ag(a1), Ag(c), Ag(d), Ag(g), Ag(h), Ag(t), Ag(x), Ag(y), and Ag(z). The data are compared with results obtained from 362 sera of Swiss blood donors. The antithetical behaviour of the factors Ag(a1)-Ag(d) Ag(c)-Ag(g), Ag(x)-Ag(y), and Ag(t)- Ag(z) could be confirmed on the basis of a Hardy-Weinberg analysis using the Tibetan and the Senegalese material. A total of 46 different Ag phenotypes was observed in the complete material. The new data were used for the evaluation of previously proposed genetic models for the Ag system. A revised model for the Ag chromosome is presented, assuming 5 closely linked loci, namely Ag^x/Ag^y, Ag^a(1)/Ag^d, Ag^c/Ag^g, Ag^t/Ag^Z, and Ag^h/Ag[^1]. The existence of at least 14 different haplotypes could be established, whereby some of them were observed exclusively in 1 of the 3 populations studied.

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