Abstract-This paper explains the use of a model to design an implanted blood pressure monitoring system through simulations in COMSOL Multiphysics® by using FSI Module. These measurement systems need to have a minimal blood contact to reduce the thrombus formation, bleeding, and avoid vessel occlusion, which are associated with the conventional catheter-tipbased technique. The model employs an elastic sensing cuff, wrapped around the artery section, made of silicone filled with biocompatible fluid with an immersed MEMS pressure sensor. From this mechanical interaction, the measured waveform represents a down-scaled version of the blood pressure waveform, where the simulation scale factor was 0.2859. From the analytical study, the scale factor was 0.2921, which results in an error of 2.1%. With this factor it is possible to adjust the measurement system for different medical applications.Keywords-Blood pressure, MEMS (Microelectromechanical System), measurement cuff, blood vessel. Abstract-This paper explains the use of a model to design an implanted blood pressure monitoring system through simulations in COMSOL Multiphysics® by using FSI Module. These measurement systems need to have a minimal blood contact to reduce the thrombus formation, bleeding, and avoid vessel occlusion, which are associated with the conventional catheter-tip-based technique. The model employs an elastic sensing cuff, wrapped around the artery section, made of silicone filled with bio-compatible fluid with an immersed MEMS pressure sensor. From this mechanical interaction, the measured waveform represents a down-scaled version of the blood pressure waveform, where the simulation scale factor was 0.2859. From the analytical study, the scale factor was 0.2921, which results in an error of 2.1%. With this factor it is possible to adjust the measurement system for different medical applications.