No abstract

No abstract

That acrocephaly and syndactylism occur in combination has been generally appreciated since 1906, when the French pediatrician, Apert,1 published the report of eight cases discovered in the literature and of one case from personal experience. Inasmuch as all the subjects exhibited deformities of the head, hands and feet so similar as to seem almost identical, Apert believed that the combination constituted a clinical entity. Accordingly, he gave to it the name "acrocephalosyndactylism." Since the publication of Apert's paper, other cases have been reported. We have been able to collect from the literature eleven cases exactly like those in Apert's series, and four others presenting the same deformity of the head but much less extensive deformities of the extremities. In addition, we have found four cases in which there was a characteristic affection of the head with slight malformations of the extremities, probably of the same nature as the malformations in the other cases but in the absence of exact description not proven. Including the cases of Apert's series and the patient who came under our own observation, made the subject of special report in this paper, the total number amounts to twenty-nine. Ten of the twenty-nine cases are reported from England, eight from France, four from Sweden, three from the United States, and one each from Italy, Germany, South America and Denmark. It is remarkable that only one case comes from German sources. Moreover, we have been able to add to the above series two cases of scaphocephaly with malformations of the extremities, one case found reported in the literature and one from personal observation.

No abstract

Intestinal intoxication, while perhaps less frequently seen now than formerly, is still not an uncommon condition, and one greatly feared because of incomplete knowledge in regard to pathogenesis and inadequate measures of treatment. The clinical picture is well known, and is in many respects similar to that reported in inanition fever of the new\x=req-\ born,1 Asiatic cholera,2 severe burns,3 high intestinal obstruction,4 traumatic and histamine shock,5 lethal war-gas poisoning,6 certain cases of influenza 7 and induced dehydration in animals.8 The basis for correspondence in symptoms is probably to be found in increased blood concentration, a condition common to all of these otherwise unrelated maladies. Since morbid states such as these, wholly diverse in etiology, may present a similar clinical picture, pediatricians ought to recognize the probability that intestinal intoxication, so-called, is but a symptom-