Quality of agriculture drain water was assessed from selected locations in Guntur district, Andhra Pradesh, India. Waste water samples collected from agriculture drains were analysed for quality parameters such as pH, electrical conductivity, total dissolved solids, total hardness, chlorides, carbonates, bicarbonates, calcium, magnesium, sulphates, phosphates, sodium, potassium, ammonical nitrogen, nitrates nitrogen, dissolved oxygen and chemical oxygen demand. Piper diagram, water quality indices such as sodium adsorption ratio, percent sodium, residual sodium carbonate, magnesium ratio, permeability index and potential salinity were used to assess the suitability of drain water for irrigation. The EC values of water samples ranged from 0.57-5.01 dS/m with an average value of 1.27 dS/m. Water of 16 agriculture drains were found to be unsuitable for irrigation with regard to percent sodium (%Na) and 6 drains with regard to potential salinity.