The paper presents the results of the tremor analysis carried out in two groups of women living in the North of Russia, aged 30 to 32 years old regularly engaged in physical training and not engaged in physical training. On the basis of methods for calculating the parameters of quasi-attractor in two-space dimension as a quantitative measure of real changes in neuromuscular system parameters of women with different fitness level, spaces of the quasi-attractors were used. In simplistic terms the indicator of quasi-attractor areas has already shown differences between trained and untrained individuals. It has been stated that the range of values of quasiattractor's squares in trained women varies from 0,02x10-6 to 0,96x10-6 (a.u.) and in women without physical training - 0,14x10-6 to 5,60x10-6 (a.u.). Statistical data processing has revealed differently directed changes of the studied parameters depending on the degree of women's physical training. The median values of the quasi-attractor squares were 0,82 (a.u.) in the group of women without physical training and 0,15 (a.u.) in trained women.

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Objective: to study the possibilities of Choi criteria in evaluating the objective response of metastatic colorectal cancer to transarterial chemoembolization (TACE), as well as to study the influence of the size and density of metastatic lesions on the posttreatment prognosis of the disease. Material and methods. CT data of 78 patients with colorectal cancer metastatic liver lesions before and after TACE with drug-eluted microspheres was analyzed. The posttreatment changes in the size and density of lesions were statistically analyzed. Evaluation of the treatment results was made according to Choi criteria and according to RECIST criteria. The effectiveness of both criteria was compared by analyzing progression-free survival (PFS) using the Kaplan-Meier method. The analysis of the influence of pretreatment size and density of lesions on the time to progression was done. Results. There was no significant reduction in the size of the liber lesions after TACE, but the density of the lesions decreased. According to the RECIST criteria, the stable disease was established in the majority of patients (73,1%). According to the Choi criteria, the majority of patients (65,4%) had a partial response. Response category coincided in 37,1% of observations. There were no significant differences in PFS between patients with different response categories according to RECIST criteria (p=0,052). PFS in patients with different response categories according to Choi criteria was different (p=0,000). There were no significant differences in PFS between patients with different sizes of foci before treatment (p=0,833). A higher density of foci before treatment provides higher PFS values (p=0,001). The sizes of lesions remain stable after TACE, but their density decreases. The Choi criteria are more effective in evaluating the TACE results of colorectal liver metastases than the RECIST criteria. The pretreatment lesions size is not a prognostic factor. Higher initial lesions density is associated with better treatment prognosis.

Obesity is now the most common disease in the population of economically developed countries, where up to 25% of residents have a body weight that is more than 15% higher than normal [8]. An increase in the incidence rate of about 10% over 10 years is observed [33]. The causal relationship between obesity and arterial hypertension, coronary heart disease, and type II diabetes mellitus is well known [6, 10]. At the same time, the current state of the problem of prevention, therapy and control of relapse of obesity is far from perfect. And this is primarily due to the fact that we do not fully know the pathogenesis of this disease.