This paper is devoted to theoretical and experimental studies into the thermomechanical action of laser radiation on biological tissues. The thermal stresses and strains developing in biological tissues under the effect of pulse-periodic laser radiation are theoretically modeled for a wide range of laser pulse durations. The models constructed allow one to calculate the magnitude of pressures developing in cartilaginous and eye tissues exposed to laser radiation and predict the evolution of cavitation phenomena occurring therein. The calculation results agree well with experimental data on the growth of pressure and deformations, as well as the dynamics of formation of gas bubbles, in the laser-affected tissues. Experiments on the effect of laser radiation on the trabecular region of the eye in minipigs demonstrated that there existed optimal laser irradiation regimens causing a substantial increase in the hydraulic permeability of the radiation-exposed tissue, which can be used to develop a novel glaucoma treatment method.

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Results of experimental and computational investigations devoted to energy transfer mechanisms and X-ray conversion efficiency in laser-produced plasma are presented and discussed. The layers of different thicknesses and diameters deposited on the plane mylar substrate were irradiated by the focused beam of Nd:glass laser. Spectrally, temporally, and spatially resolved measurements of soft X-ray emission have been carried out at power densities of 1013-1014 W/cm2. The conditions of “re-emission” zone formation have been established. Radiative heat conductivity is shown to be the important energy transfer mechanism in the experimental conditions under investigation.

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