The role of adjuvant treatment for patients with resected perihilar cholangiocarcinoma (PC) remains controversial, and there is no consensus regarding patient selection for adjuvant radiotherapy and chemotherapy. The objective of this study was to investigate the benefits of adjuvant treatment for patients with resected PC. Materials/Methods: Between 2001 and 2017, 205 patients with PC underwent curative resection. The patients were divided into four groups according to adjuvant treatment types: surgery alone (n Z 96), surgery with chemotherapy (CTx, n Z 66), surgery with radiotherapy (RTx, n Z 18), and surgery with chemoradiotherapy (CRT, n Z 25). Results: The median follow-up of surviving patients was 46 months (range, 9e188 months). The 5-year rates of disease free survival (DFS), overall survival (OS) for all patients were 27.2%, and 34.4%, respectively. Multivariate analysis showed that surgery with CRT was a significant prognostic factor for DFS and OS. In the subgroup analyses of the R1 resection patients, the 5-year OS of surgery with CRT, surgery with RTx, surgery with CTx, and surgery alone was 40.4%, 15.2%, 9.1%, and 7.7%, respectively. In the subgroup analyses of the positive lymph nodes and R0 resection patients, the 5-year OS of surgery with CRT, surgery with RTx, surgery with CTx, and surgery alone was 66.7%, 42.1%, 0%, and 0%, respectively. Conclusion: Adjuvant CRT is associated with improved survival in PC patients with R1 resection, or positive lymph nodes and R0 resection. Our data suggest that adjuvant RTx and CTx should be considered in high-risk resected PC patients.

Aim: The aim is to study the correlation between estimated graft weight (EGW) and actual graft weight (AGW) in potential donors for LDLT. Materials and Methods: The study cohort consisted of 133 right lobe (RL) with middle hepatic vein (MHV), 23 RL without MHV and 17 left lobe (LL) grafts assessed between August 2018 and August 2020. EGW was calculated using semi-automated volumetry technique in Philips IntelliSpace portal workstation and AGW was measured intra-operatively by the transplant team after graft retrieval from the donor. To find the agreement between AGW and EGW, intra-class correlation co-efficient (ICC) was computed. To find the degree of correlation between EGW and AGW, Spearman’s rho correlation co-efficient was computed. Bland Altman plot was used for assessing the level of agreement between two methods. Results: The mean age of donors was 38.9 +/- 9.9 years (Female:Male::121:52). The correlation between EGW and AGW for all three types of grafts was significant (p<0.001). RL with MHV: Spearman’s rho r=0.786, ICC=0.883; RL without MHV: Spearman’s rho r= 0.968, ICC=0.986 and LL: Spearman’s rho r= 0.809, ICC=0.937. Bland Altman’s analysis showed that CT volumetry overestimated 5 and underestimated 1 RL grafts with MHV, overestimated 1 RL grafts without MHV and underestimated 1 LL grafts. Conclusion: CT volumetry has a definitive role in the pre-operative evaluation of prospective liver donors. EGW calculated by semi-automated CT volumetry in potential LDLT donors is accurate and correlates well with AGW measured intra-operatively for both right and left lobe grafts.