Orthodontic springs were placed across the interparietal suture in twenty 30-day-old male Wistar rats, in order to study the effect of tensile forces on the initial biological response of sutural tissues. Five groups of different force duration and magnitude were used: a 6 hours (h), 0 mN group; 6 h and 24 h, 50 mN groups; and 6 h and 24 h, 100 mN groups. One group of four animals served as a control. The animals were injected with tritiated proline 3 hours prior to the end of the experiment. Undecalcified 5 microns sections were used for (enzyme) histology and autoradiography in order to quantify several morphometric variables. The data were analysed with multivariate analysis of variance and contrast calculations. Application of the springs led to significant sutural widening within 6 hours. The concentration of fibroblasts in the suture also increased significantly within 6 hours. The volume of the suture and the incorporation of 3H-proline in the fibrous part of the suture and in the osteoid along the sutural bony edges were significantly increased after 24 hours of force. In general, force duration had a greater impact on histological events than force magnitude.

The demand for improved and low priced intervention methods for coronary artery obstruction has led to the development of a non-surgical desobstruction technique. This in turn requires new diagnostical methods. This paper reports the work in progress of this technique. The catheter in development is an advanced micro-mechanical device with an external diameter of 2 mm.