The aim of this study was to assess the burden of PE, in terms of mortality and health-related quality of life (HrQoL), as a function of patient characteristics, across Europe. MethOds: The PREFER in VTE registry was a prospective, observational, multicenter study conducted in seven European countries (France, Italy, Spain, UK, and DACH (Germany, Switzerland and Austria)). Venous thromboembolism (VTE) patients, following an acute event (index event), were recruited and followed at 1, 3, 6 and 12 months. The study sample was 1399 patients with PE. Subgroup analysis by country and with active cancer were conducted. The association between patient characteristics and mortality/HrQoL (EQ-5D-5L) were examined using a regression approach with the total sample. Results: Average mortality rate at 12 months was 8.1%, varying between observed regions (1.4% in DACH to 16.8% in Italy), and substantially differed between patients with active cancer and those without (42.7% vs. 4.7%). Cancer was one of the most significant predictors for mortality, other predictors include age, BMI, more than 5 days bed rest, vascular disease, previous AF, smoking history and symptoms of palpitations. EQ-5D-5L index score at baseline (right after the index event) was 0.712 (SD: 0.265), and gradually improved to 0.835 (0.212) at 12 months. When scoring non-survivors at zero, average quality of life decreased to 0.743 at 12 months. Similarly, the index scores varied between observed countries and cancer subgroups. Active cancer, previous stroke and provoked VTE are amongst other significant factors for predicting index scores. cOnclusiOns: PE is associated with a substantial burden of illness -increasing mortality rate and decreasing HrQoL. Country variation exist and active cancer has a significantly large impact on PE burden.

Objectives: The present study aimed to evaluate the knowledge among hypertensive patients. MethOds: A questionnaire based descriptive, cross-sectional study was conducted in the outpatient setting of Benazir Bhutto hospital Rawalpindi, Sir Ganga Ram hospital Lahore, Nishtar hospital Multan and Bahawal Victoria hospital in Bahawalpur, Pakistan. Knowledge regarding hypertension was assessed by using Hypertension Fact Questionnaire. Statistical package for social sciences (SPSS) version 20.0 was used to analyze data. Descriptive statistics was used to summarize data and chi square test was used to assess the association between categorical and dependent variable. Non parametric tests (Mann Whitney U test and Kruskal Wallis test) were used to find statistical difference in the scores based on categorical variable. Results: Among the 340 participants, mean age (SD) was 50.25 (11.49), with 60.6% of females dominating the entire cohort. Majority of the participants (73.6%) belonged to urban area. About 35.6% had HTN for more than 5 years, 53.5% had family history of hypertension and 53.2% had hypertension along with co-morbidity. The mean score of hypertension knowledge was 8.43+3.44. The result of the study demonstrated that hypertensive patients have average knowledge. cOnclusiOns: The current study findings revealed the importance of educational programs to increase the awareness of the patients regarding the importance of lifestyle modifications and medication for control of disease.