With the opening of the hemophilia center in Oct. 1972 an intensive replacement therapy with clotting factor concentrates was started the first time for many patients. Concerning the induced liver damages, three years later the following résumée could be drawn. From 113 examined patients 17(19%) acquired an icteric hepatitis(i.h.). Excluding 2 cases the interval between beginning of intensive clotting factor substitution and outbreak of i.h. was found to be 46 days in the average (13-117).1o 827 u (1 8oo-27 99o) of clotting factor concentrates had been injected until to this moment.(The average consumption by the 113 examined patients from Oct.1972 to Oct. 1975 was 57 186 u per patient and year.) In Oct.197 5 the distribution of Anti-HBs and HBs-Ag positive patients(radio immune assay) was: Frequently transfused cases (more than 15 000 u per year): Anti-HBs 86%, HBs-Ag 8%(total 94%); less frequently transfused cases”: Anti-HBs 71,5%, HBs-Ag 9,5%(total 81%). In 18 patients(not identical to those with i.h.) liver biopsies could be performed with the. following results: chronic hepatitis: 9, subsided hepatitis without activity: 4, alcoholic liver damages: 3, acute dystrophia: 1, cholanqiolitis: 1.

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